Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier.

PloS one - 1 Jan 2012

John Susan, Thiebach Lars, Frie Christian, Mokkapati Sharada, Bechtel Manuela, Nischt Roswitha, Rosser-Davies Sally, Paulsson Mats, Smyth Neil

Abstract excerpt

Transglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization. Transglutaminase 1 is crucial in developing the epidermal barrier, however the skin also contains other family members, in particular TGase 3. This isoform is highly expressed in the cornified layer, where it is believed to stabilize the epidermis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cornea
Share to Epidermal Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epidermis

Share to Hair Follicle

Share to Microscopy, Electron, Scanning

Share to Microscopy, Electron, Transmission

Share to Transglutaminases

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 22496784
DOI: 10.1371/journal.pone.0034252
PMCID: PMC3319564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier.PMID 22496784Read ↗

Transglutaminase 3: The Involvement in Epithelial Differentiation and CancerSemantic proximity Read ↗

Characterization of TG2 and TG1-TG2 double knock-out mouse epidermis.Semantic proximity Read ↗

A homolog of Drosophila grainy head is essential for epidermal integrity in mice.Semantic proximity Read ↗

The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouseSemantic proximity Read ↗

Desmoglein 3 anchors telogen hair in the follicle.Semantic proximity Read ↗

Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion.Semantic proximity Read ↗

Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3Semantic proximity Read ↗

Transglutaminases in autoimmune and inherited skin diseases: The phenomena of epitope spreading and functional compensation.Semantic proximity Read ↗

The mouse wellhaarig (we) mutations result from defects in epidermal-type transglutaminase 3 (Tgm3).Semantic proximity Read ↗

Loss of desmocollin 3 in mice leads to epidermal blistering.Semantic proximity Read ↗

Loss of ceramide synthase 3 causes lethal skin barrier disruptionSemantic proximity Read ↗

Roles of GasderminA3 in Catagen-Telogen Transition During Hair Cycling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.