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Article

G-quadruplex formation in the Oct4 promoter positively regulates Oct4 expression.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Feb 2017

Renčiuk Daniel, Ryneš Jan, Kejnovská Iva, Foldynová-Trantírková Silvie, Andäng Michael, Trantírek Lukáš, Vorlíčková Michaela

Abstract excerpt

The Oct4 gene codes for a transcription factor that plays a critical role in the maintenance of pluripotency in embryonic and cancer stem cells. Its expression thus has to be tightly regulated. We performed biophysical characterization of the promoter region using a combination of UV absorption, CD, and NMR spectroscopies, native PAGE and chemical probing, which was followed by functional studies involving...

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PMID: 27863263
DOI: 10.1016/j.bbagrm.2016.11.002

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