Article
The G-quadruplex augments translation in the 5' untranslated region of transforming growth factor β2.
Biochemistry - 5 Mar 2013
Agarwala Prachi, Pandey Satyaprakash, Mapa Koyeli, Maiti Souvik
Abstract excerpt
Transforming growth factor β2 (TGFβ2) is a versatile cytokine with a prominent role in cell migration, invasion, cellular development, and immunomodulation. TGFβ2 promotes the malignancy of tumors by inducing epithelial-mesenchymal transition, angiogenesis, and immunosuppression. As it is well-documented that nucleic acid secondary structure can regulate gene expression, we assessed whether any secondary motif...
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