Article

Biophysical and functional studies of potential G-quadruplex motifs from the proximal GATA4 gene promoter

2015-01-01

Abstract excerpt

GATA4 is well known as a cardiac transcription factor and recently has also been implicated in several cancers. Therefore, a fundamental understanding of its gene regulation is currently of high interest. It has been suggested that guanine-rich motifs found in gene promoters could potentially adopt a G-quadruplex DNA structure and play a role in regulating gene expression. Two conserved-potential G-quadruplex moti...

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Literature Corpus work: 24b0b214-2ae0-5408-a62a-2df976a8945d
DOI: 10.25560/44979

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