Article
Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3.
Diabetes/metabolism research and reviews - 1 May 2017
Muller Yunhua L, Piaggi Paolo, Chen Peng, Wiessner Gregory, Okani Chidinma, Kobes Sayuko, Knowler William C, Bogardus Clifton, Hanson Robert L, Baier Leslie J
Abstract excerpt
BACKGROUND: Eight new loci for type 2 diabetes mellitus (T2DM) were identified in an East Asian genome-wide association study meta-analysis. We assess tag SNPs across these loci for associations with T2DM in American Indians. METHODS: A total of 435 SNPs that tag (R2 ≥ .85) common variation across the 8 loci were analyzed for association with T2DM (n = 7710), early onset T2DM (n = 1060), body mass index...
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