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Article

Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes.

Journal of molecular endocrinology - 1 Feb 2017

Wen Xianjie, Yang Yisheng

Abstract excerpt

GLI-similar 3 (GLIS3), a member of the Krüppel-like zinc finger protein subfamily, is predominantly expressed in the pancreas, thyroid and kidney. Glis3 mRNA can be initially detected in mouse pancreas at embryonic day 11.5 and is largely restricted to β cells, pancreatic polypeptide-expressing cells, as well as ductal cells at later stage of pancreas development. Mutations in GLIS3 cause a neonatal diabetes...

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Source

Identifiers

PMID: 27899417
DOI: 10.1530/JME-16-0232

Genes

GLIS3
FOXA2
MAFA
NEUROD1
PDX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes.PMID 27899417Read ↗

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Glis3 Regulates Neurogenin 3 Expression in Pancreatic β-Cells and Interacts with Its Activator, Hnf6Semantic proximity Read ↗

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