Article
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
Nature genetics - 11 Dec 2011
Cho Yoon Shin, Chen Chien-Hsiun, Hu Cheng, Long Jirong, Ong Rick Twee Hee, Sim Xueling, Takeuchi Fumihiko, Wu Ying, Go Min Jin, Yamauchi Toshimasa, Chang Yi-Cheng, Kwak Soo Heon, Ma Ronald C W, Yamamoto Ken, Adair Linda S, Aung Tin, Cai Qiuyin, Chang Li-Ching, Chen Yuan-Tsong, Gao Yutang, Hu Frank B, Kim Hyung-Lae, Kim Sangsoo, Kim Young Jin, Lee Jeannette Jen-Mai, Lee Nanette R, Li Yun, Liu Jian Jun, Lu Wei, Nakamura Jiro, Nakashima Eitaro, Ng Daniel Peng-Keat, Tay Wan Ting, Tsai Fuu-Jen, Wong Tien Yin, Yokota Mitsuhiro, Zheng Wei, Zhang Rong, Wang Congrong, So Wing Yee, Ohnaka Keizo, Ikegami Hiroshi, Hara Kazuo, Cho Young Min, Cho Nam H, Chang Tien-Jyun, Bao Yuqian, Hedman Åsa K, Morris Andrew P, McCarthy Mark I, Takayanagi Ryoichi, Park Kyong Soo, Jia Weiping, Chuang Lee-Ming, Chan Juliana C N, Maeda Shiro, Kadowaki Takashi, Lee Jong-Young, Wu Jer-Yuarn, Teo Yik Ying, Tai E Shyong, Shu Xiao Ou, Mohlke Karen L, Kato Norihiro, Han Bok-Ghee, Seielstad Mark
Abstract excerpt
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The...
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