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Article

Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas.

Diabetologia - 1 Feb 2024

Meulebrouck Sarah, Scherrer Victoria, Boutry Raphaël, Toussaint Bénédicte, Vaillant Emmanuel, Dechaume Aurélie, Loiselle Hélène, Balkau Beverley, Charpentier Guillaume, Franc Sylvia, Marre Michel, Baron Morgane, Vaxillaire Martine, Derhourhi Mehdi, Boissel Mathilde, Froguel Philippe, Bonnefond Amélie

Abstract excerpt

AIMS/HYPOTHESIS: GLIS3 encodes a transcription factor involved in pancreatic beta cell development and function. Rare pathogenic, bi-allelic mutations in GLIS3 cause syndromic neonatal diabetes whereas frequent SNPs at this locus associate with common type 2 diabetes risk. Because rare, functional variants located in other susceptibility genes for type 2 diabetes have already been shown to strongly increase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38051360
DOI: 10.1007/s00125-023-06035-x
PMCID: PMC10789827

Genes

GLIS3
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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