Article
Mouse Model of a Human STAT4 Point Mutation That Predisposes to Disseminated Coccidiomycosis.
ImmunoHorizons - 11 Feb 2022
Powell Daniel A, Hsu Amy P, Shubitz Lisa F, Butkiewicz Christine D, Moale Hilary, Trinh Hien T, Doetschman Thomas, Georgieva Teodora G, Reinartz Dakota M, Wilson Justin E, Orbach Marc J, Holland Steven M, Galgiani John N, Frelinger Jeffrey A
Abstract excerpt
STAT4 plays a critical role in the generation of both innate and adaptive immune responses. In the absence of STAT4, Th1 responses, critical for resistance to fungal disease, do not occur. Infection with the dimorphic fungus, Coccidioides, is a major cause of community-acquired pneumonia in the endemic regions of Arizona and California. In some people and often for unknown reasons, coccidioidal infection results...
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