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Article

The autoimmune susceptibility gene, PTPN2, restricts expansion of a novel mouse adherent-invasive E. coli.

Gut microbes - 1 Nov 2020

Shawki Ali, Ramirez Rocio, Spalinger Marianne R, Ruegger Paul M, Sayoc-Becerra Anica, Santos Alina N, Chatterjee Pritha, Canale Vinicius, Mitchell Jonathan D, Macbeth John C, Gries Casey M, Tremblay Michel L, Hsiao Ansel, Borneman James, McCole Declan F

Abstract excerpt

Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene increase IBD risk and are associated with altered microbiome population dynamics in IBD. Expansion of intestinal pathobionts, such as adherent-invasive E. coli (AIEC), is...

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Source

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Identifiers

PMID: 32586195
DOI: 10.1080/19490976.2020.1775538
PMCID: PMC7524159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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