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Article

Long-Range Control of Renin Gene Expression in Tsukuba Hypertensive Mice.

PloS one - 1 Jan 2016

Ushiki Aki, Matsuzaki Hitomi, Ishida Junji, Fukamizu Akiyoshi, Tanimoto Keiji

Abstract excerpt

Renin, a rate-limiting enzyme in the renin-angiotensin system, is regulated to maintain blood pressure homeostasis: renin gene expression in the kidney is suppressed in a hypertensive environment. We found that expression of a 15-kb human RENIN (hREN) transgene was aberrantly upregulated (>4.2-fold), while the endogenous mouse renin (mRen) gene was suppressed (>1.7-fold) in Tsukuba hypertensive mice (THM), a...

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Identifiers

PMID: 27861631
DOI: 10.1371/journal.pone.0166974
PMCID: PMC5115840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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