Article
Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 2009
Xu Di, Borges Giulianna R, Grobe Justin L, Pelham Christopher J, Yang Baoli, Sigmund Curt D
Abstract excerpt
The primary product of the renin gene is preprorenin. A signal peptide sorts renin to the secretory pathway in juxtaglomerular cells where it is released into the circulation to initiate the renin-angiotensin system cascade. In the brain, transcription of renin occurs from an alternative promoter encoding an mRNA starting with a new first exon (exon 1b). Exon 1b initiating transcripts skip over the classical...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.