Article

Genetic reprogramming by brief inhibition of the renin-angiotensin system in spontaneously hypertensive rats leads to persistently reduced kidney renin and low blood pressure

2023-07-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin-angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously hypertensive rat (SHR). The kidney is involved in this reprogramming, but relevant genetic changes are unknown. <h4>METHODS</h4> In SHR, we st...

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Literature Corpus work: 3f3026b1-097f-5026-97d1-493aaa2cae85
DOI: 10.1101/2023.07.30.551193

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Genetic reprogramming by brief inhibition of the renin-angiotensin system in spontaneously hypertensive rats leads to persistently reduced kidney renin and low blood pressureDOI 10.1101/2023.07.30.551193Read

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