Article
Genetic dissection of the fatty liver QTL Fl1sa by using congenic mice and identification of candidate genes in the liver and epididymal fat.
BMC genetics - 17 Nov 2016
Suzuki Miyako, Kobayashi Misato, Ohno Tamio, Kanamori Shinsaku, Tateishi Soushi, Murai Atsushi, Horio Fumihiko
Abstract excerpt
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disease caused by interactions between environmental and genetic factors. The SMXA-5 mouse is a high-fat diet-induced fatty liver model established from SM/J and A/J strains. We have previously identified Fl1sa, a quantitative trait locus (QTL) for fatty liver on chromosome 12 (centromere-53.06 Mb) of SMXA-5 mice. However, the chromosomal...
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