Article
Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet.
G3 (Bethesda, Md.) - 23 Jan 2015
Pasricha Sarina, Kenney-Hunt Jane, Anderson Kristy, Jafari Nadereh, Hall Rabea A, Lammert Frank, Cheverud James, Green Richard M
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent form of human hepatic disease and feeding mice a high-fat, high-caloric (HFHC) diet is a standard model of NAFLD. To better understand the genetic basis of NAFLD, we conducted an expression quantitative trait locus (eQTL) analysis of mice fed a HFHC diet. Two-hundred sixty-five (A/J × C57BL/6J) F2 male mice were fed a HFHC diet for 8 wk. eQTL analysis...
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