Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.

Nature genetics - 1 Jan 2001

Péterfy M, Phan J, Xu P, Reue K

Abstract excerpt

Mice carrying mutations in the fatty liver dystrophy (fld) gene have features of human lipodystrophy, a genetically heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance. Through positional cloning, we have isolated the gene responsible and characterized two independent mutant alleles, fld and fld(2J). The gene (Lpin1) encodes a novel nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Fatty Liver
Share to Hypertriglyceridemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leptin

Share to Lipodystrophy

Share to Mice, Inbred C3H

Share to Phosphatidate Phosphatase

Share to Radiation Hybrid Mapping

Source

Identifiers

PMID: 11138012
DOI: 10.1038/83685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.PMID 11138012Read ↗

The lipin family: mutations and metabolism.Semantic proximity Read ↗

Lipins: multifunctional lipid metabolism proteins.Semantic proximity Read ↗

Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.Semantic proximity Read ↗

Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humansSemantic proximity Read ↗

A mouse model of conditional lipodystrophy.Semantic proximity Read ↗

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in miceSemantic proximity Read ↗

The fat and thin of lipin.Semantic proximity Read ↗

Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations.Semantic proximity Read ↗

Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.Semantic proximity Read ↗

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.Semantic proximity Read ↗

Clinical and molecular characterization of a severe form of partial lipodystrophy expanding the phenotype of PPARγ deficiency.Semantic proximity Read ↗

Subcellular localization and role of lipin-1 in human macrophages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.