Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes.

doi:10.1007/s00125-007-0700-6

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Article

Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes.

Diabetologia - 1 Aug 2007

Itoi-Babaya M, Ikegami H, Fujisawa T, Ueda H, Nojima K, Babaya N, Kobayashi M, Noso S, Kawaguchi Y, Yamaji K, Shibata M, Ogihara T

Abstract excerpt

AIMS/HYPOTHESIS: Obesity and fatty liver are commonly associated with type 2 diabetes, but the genetic and functional bases linking fatty liver with obesity and diabetes are largely unknown. Our aim was to investigate the association of fatty liver with obesity and other diabetes-related phenotypes and to define the genetic control of obesity and fatty liver. MATERIALS AND METHODS: We established 306 F2 mice by...

Topics

Animals
Body Mass Index
Chromosomes, Mammalian
Diabetes Mellitus, Type 2
Disease Models, Animal
Fatty Liver
Female
Genotype
Male
Mice
Mice, Inbred C3H
Obesity
Phenotype
Quantitative Trait Loci

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Identifiers

PMID: 17549450
DOI: 10.1007/s00125-007-0700-6

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