Article
Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15.
Gastroenterology - 1 Dec 2002
Hillebrandt Sonja, Goos Claudia, Matern Siegfried, Lammert Frank
Abstract excerpt
BACKGROUND & AIMS: Host genetic factors are likely to contribute to the variable course of hepatic fibrosis in response to chronic liver injury. Similarly, the fibrotic response differs among inbred mouse strains after challenge with CCl(4). Our aim was to identify unknown susceptibility loci for hepatic fibrosis in a cross between fibrosis-susceptible and -resistant inbred mice. METHODS: Seven inbred mouse...
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