Article
Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12.
BMC genetics - 6 Jun 2016
Kobayashi Misato, Suzuki Miyako, Ohno Tamio, Tsuzuki Kana, Taguchi Chie, Tateishi Soushi, Kawada Teruo, Kim Young-Il, Murai Atsushi, Horio Fumihiko
Abstract excerpt
BACKGROUND: The SMXA-5 mouse is an animal model of high-fat diet-induced fatty liver. The major QTL for fatty liver, Fl1sa on chromosome 12, was identified in a SM/J × SMXA-5 intercross. The SMXA-5 genome consists of the SM/J and A/J genomes, and the A/J allele of Fl1sa is a fatty liver-susceptibility allele. The existence of the responsible genes for fatty liver within Fl1sa was confirmed in A/J-12(SM) consomic...
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