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Article

Long-Chain Fatty Acyl Coenzyme A Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Feb 2017

Rosen Brandon C, Dillon Nicholas A, Peterson Nicholas D, Minato Yusuke, Baughn Anthony D

Abstract excerpt

Pyrazinamide (PZA) is a first-line tuberculosis (TB) drug that has been in clinical use for 60 years yet still has an unresolved mechanism of action. Based upon the observation that the minimum concentration of PZA required to inhibit the growth of Mycobacterium tuberculosis is approximately 1,000-fold higher than that of other first-line drugs, we hypothesized that M. tuberculosis expresses factors that mediate...

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Identifiers

PMID: 27855077
DOI: 10.1128/AAC.02130-16
PMCID: PMC5278697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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