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Article

Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.

Antimicrobial agents and chemotherapy - 1 Dec 2010

Baughn Anthony D, Deng Jiaoyu, Vilchèze Catherine, Riestra Angelica, Welch John T, Jacobs William R, Zimhony Oren

Abstract excerpt

The pyrazinamide (PZA) analog 5-chloropyrazinamide (5-Cl PZA) is active against mycobacterial species, including PZA-resistant strains of Mycobacterium tuberculosis. In M. smegmatis, overexpression of the type 1 fatty acid synthase (FAS I) confers resistance to 5-Cl PZA, a potent FAS I inhibitor. Since M. tuberculosis and M. bovis cannot tolerate FAS I overexpression, 5-Cl PZA resistance mutations have yet to be...

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Identifiers

PMID: 20876380
DOI: 10.1128/AAC.00529-10
PMCID: PMC2981270

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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