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Article

Pyrazinamide triggers degradation of its target aspartate decarboxylase.

Nature communications - 3 Apr 2020

Gopal Pooja, Sarathy Jickky Palmae, Yee Michelle, Ragunathan Priya, Shin Joon, Bhushan Shashi, Zhu Junhao, Akopian Tatos, Kandror Olga, Lim Teck Kwang, Gengenbacher Martin, Lin Qingsong, Rubin Eric J, Grüber Gerhard, Dick Thomas

Abstract excerpt

Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the prodrug pyrazinamide (PZA), interrupts biosynthesis of coenzyme A in Mycobacterium tuberculosis by binding to aspartate decarboxylase PanD. While most drugs act by inhibiting protein function upon target binding, we find here that...

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Identifiers

PMID: 32245967
DOI: 10.1038/s41467-020-15516-1
PMCID: PMC7125159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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