Article

Pyrazinamide triggers degradation of its target aspartate decarboxylase

2019-06-18

Abstract excerpt

The introduction of pyrazinamide (PZA) in the tuberculosis drug regimen shortened treatment from 12 to 6 months 1 . PZA is a prodrug that is activated by a Mycobacterium tuberculosis (Mtb) amidase to release its bioactive component pyrazinoic acid (POA) 2 . Aspartate decarboxylase PanD, a proenzyme activated by autocatalytic cleavage (Supplementary Fig. 1A, 3 ) and required for Coenzyme A (CoA) biosynthesis, e...

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Literature Corpus work: eebe0430-6c1a-5d4a-973a-6b8ce06bcf6a
DOI: 10.1101/674416

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