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Article

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

Nature communications - 19 Sept 2017

Yadon Adam N, Maharaj Kashmeel, Adamson John H, Lai Yi-Pin, Sacchettini James C, Ioerger Thomas R, Rubin Eric J, Pym Alexander S

Abstract excerpt

Tuberculosis chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is being threatened by emerging drug resistance. Resistance is mediated through mutations in the bacterial gene pncA. Methods for testing pyrazinamide susceptibility are difficult and rarely performed, and this means that the full spectrum of pncA alleles that confer clinical resistance to pyrazinamide is unknown. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28928454
DOI: 10.1038/s41467-017-00721-2
PMCID: PMC5605632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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