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Article

Mutational Signature Changes in Patients With Metastatic Squamous Cell Carcinoma of the Anal Canal.

The oncologist - 4 Apr 2024

LaPelusa Michael, Cann Christopher, Ciombor Kristen K, Eng Cathy

Abstract excerpt

PURPOSE: We examined the concordance of genetic mutations between pretreatment tumor tissue and posttreatment circulating tumor DNA (ctDNA) in patients with metastatic squamous cell carcinoma of the anal canal (SCCA) and assessed the impact of therapy on this concordance. METHODS: We analyzed next-generation sequencing reports from pretreatment tumor tissue and posttreatment ctDNA in 11 patients with metastatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38103030
DOI: 10.1093/oncolo/oyad326
PMCID: PMC10994269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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