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Article

Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming.

Cell reports - 15 Nov 2016

Clayton Hannah W, Osipovich Anna B, Stancill Jennifer S, Schneider Judsen D, Vianna Pedro G, Shanks Carolyn M, Yuan Weiping, Gu Guoqiang, Manduchi Elisabetta, Stoeckert Christian J, Magnuson Mark A

Abstract excerpt

Using a transgenic mouse model to express MafA, Pdx1, and Neurog3 (3TF) in a pancreatic acinar cell- and doxycycline-dependent manner, we discovered that the outcome of transcription factor-mediated acinar to β-like cellular reprogramming is dependent on both the magnitude of 3TF expression and on reprogramming-induced inflammation. Overly robust 3TF expression causes acinar cell necrosis, resulting in marked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27851966
DOI: 10.1016/j.celrep.2016.10.068
PMCID: PMC5131369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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