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Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-Mediated Reprogramming

14 May 2012

Abstract excerpt

AIMS/HYPOTHESIS: Duct cells isolated from adult human pancreas can be reprogrammed to express islet beta cell genes by adenoviral transduction of the developmental transcription factor neurogenin3 (Ngn3). In this study we aimed to fully characterize the extent of this reprogramming and intended to improve it. METHODS: The extent of the Ngn3-mediated duct-to-endocrine cell reprogramming was measured employing...

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PMID: 22606327
DOI: 10.1371/journal.pone.0037055

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