Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic Ducts

Abstract excerpt

Direct lineage reprogramming can convert readily available cells in the body into desired cell types for cell replacement therapy. This is usually achieved through forced activation or repression of lineage-defining factors or pathways. In particular, reprogramming toward the pancreatic β cell fate has been of great interest in the search for new diabetes therapies. It has been suggested that cells from various...

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