Article

Direct reprogramming of human fibroblasts into insulin-producing cells by transcription factors

2021-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Direct lineage reprogramming of one somatic cell into another bypassing an intermediate pluripotent state has emerged as an alternative to embryonic or induced pluripotent stem cell differentiation to generate clinically relevant cell types. One cell type of clinical interest is the pancreatic β cell that secretes insulin and whose loss and/or dysfunction leads to diabetes. Generation of functio...

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Literature Corpus work: d24130df-5a2b-5992-b7ad-fa01150174f5
DOI: 10.1101/2021.08.05.455196

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