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Article

Ribonucleotide incorporation by yeast DNA polymerase ζ.

DNA repair - 1 Jun 2014

Makarova Alena V, Nick McElhinny Stephanie A, Watts Brian E, Kunkel Thomas A, Burgers Peter M

Abstract excerpt

During replication in yeast, the three B family DNA replicases frequently incorporate ribonucleotides (rNMPs) into DNA, and their presence in the nuclear genome can affect genome stability. This prompted us to examine ribonucleotide incorporation by the fourth B family member, Pol ζ, the enzyme responsible for the majority of damage-induced mutagenesis in eukaryotes. We first show that Pol ζ inserts rNMPs into...

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Identifiers

PMID: 24674899
DOI: 10.1016/j.dnarep.2014.02.017
PMCID: PMC4402711

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PCNA

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