Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A.

doi:10.1186/s12881-016-0341-z

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Article

Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A.

BMC medical genetics - 15 Nov 2016

Cadzow Murray, Merriman Tony R, Boocock James, Dalbeth Nicola, Stamp Lisa K, Black Michael A, Visscher Peter M, Wilcox Phillip L

Abstract excerpt

BACKGROUND: The gene PPARGC1A, in particular the Gly482Ser variant (rs8192678), had been proposed to be subject to natural selection, particularly in recent progenitors of extant Polynesian populations. Reasons include high levels of population differentiation and increased frequencies of the derived type 2 diabetes (T2D) risk 482Ser allele, and association with body mass index (BMI) in a small Tongan population....

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PMID: 27846814
DOI: 10.1186/s12881-016-0341-z
PMCID: PMC5111290

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Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A.PMID 27846814Read ↗

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