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Article

Can evidence from genome-wide association studies and positive natural selection surveys be used to evaluate the thrifty gene hypothesis in East Asians?

PloS one - 1 Jan 2014

Koh Xuan-Han, Liu Xuanyao, Teo Yik-Ying

Abstract excerpt

Body fat deposition and distribution differ between East Asians and Europeans, and for the same level of obesity, East Asians are at higher risks of Type 2 diabetes (T2D) and other metabolic disorders. This observation has prompted the reclassifications of body mass index thresholds for the definitions of "overweight" and "obese" in East Asians. However, the question remains over what evolutionary mechanisms have...

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PMID: 25337808
DOI: 10.1371/journal.pone.0110974
PMCID: PMC4206456

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