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Article

Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes.

American journal of human genetics - 6 Feb 2014

Ayub Qasim, Moutsianas Loukas, Chen Yuan, Panoutsopoulou Kalliope, Colonna Vincenza, Pagani Luca, Prokopenko Inga, Ritchie Graham R S, Tyler-Smith Chris, McCarthy Mark I, Zeggini Eleftheria, Xue Yali

Abstract excerpt

We have investigated the evidence for positive selection in samples of African, European, and East Asian ancestry at 65 loci associated with susceptibility to type 2 diabetes (T2D) previously identified through genome-wide association studies. Selection early in human evolutionary history is predicted to lead to ancestral risk alleles shared between populations, whereas late selection would result in...

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Identifiers

PMID: 24412096
DOI: 10.1016/j.ajhg.2013.12.010
PMCID: PMC3928649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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