Article
Single nucleotide polymorphisms of thrifty genes for energy metabolism: evolutionary origins and prospects for intervention to prevent obesity-related diseases.
Biochemical and biophysical research communications - 12 Jul 2002
Kagawa Yasuo, Yanagisawa Yoshiko, Hasegawa Kyoko, Suzuki Hisano, Yasuda Kazuto, Kudo Hideki, Abe Mieko, Matsuda Sanae, Ishikawa Yuko, Tsuchiya Noriko, Sato Aya, Umetsu Kazuo, Kagawa Yoshiko
Abstract excerpt
The "thrifty" genotype and phenotype that save energy are detrimental to the health of people living in affluent societies. Individual differences in energy metabolism are caused primarily by single nucleotide polymorphisms (SNPs), some of which promote the development of obesity/type 2 diabetes mellitus. In this review, four major questions are addressed: (1) Why did regional differences in energy metabolism...
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