Natural selection signatures of 65 syndromic and 8 monogenic obesity genes in 7 ethnic groups do not support the thrifty genotype hypothesis.

doi:10.1016/j.metabol.2025.156353

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Article

Natural selection signatures of 65 syndromic and 8 monogenic obesity genes in 7 ethnic groups do not support the thrifty genotype hypothesis.

Metabolism: clinical and experimental - 1 Oct 2025

El Kouche Sandra, Meyre David

Abstract excerpt

BACKGROUND: The "thrifty genotype hypothesis" states that gene variants promoting efficient fat deposition may have been advantaged by natural selection to allow human survival during famine. Nowadays, such genes are rendered detrimental by progress as they promote fat deposition in preparation for a famine that never comes, resulting in widespread obesity. Obesity is genetically heterogeneous, with a continuum...

Topics

Humans
Obesity
Selection, Genetic
Genotype
Ethnicity
Genetic Predisposition to Disease
Male
Female

Source

Open in PubMed

Identifiers

PMID: 40730766
DOI: 10.1016/j.metabol.2025.156353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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