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Article

Polygenic and single-locus selection on BMI during Polynesian expansion.

Journal of human genetics - 1 May 2026

Miwa Hanako, Isshiki Mariko, Naka Izumi, Kimura Ryosuke, Inaoka Tsukasa, Matsumura Yasuhiro, Ohashi Jun

Abstract excerpt

The 'thrifty' variant hypothesis, which posits that certain genetic adaptations promoting efficient energy storage during periods of food scarcity, has been invoked to explain the high prevalence of obesity in modern human populations. Although several candidate variants have been proposed, the timing and effects of these variants on body mass index (BMI) in specific populations remain poorly understood. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41398039
DOI: 10.1038/s10038-025-01441-y
PMCID: PMC13109058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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