Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans.

BMC medical genetics - 18 Jan 2011

Myles Sean, Lea Rod A, Ohashi Jun, Chambers Geoff K, Weiss Joerg G, Hardouin Emilie, Engelken Johannes, Macartney-Coxson Donia P, Eccles David A, Naka Izumi, Kimura Ryosuke, Inaoka Tsukasa, Matsumura Yasuhiro, Stoneking Mark

Abstract excerpt

BACKGROUND: the thrifty gene hypothesis posits that, in populations that experienced periods of feast and famine, natural selection favoured individuals carrying thrifty alleles that promote the storage of fat and energy. Polynesians likely experienced long periods of cold stress and starvation during their settlement of the Pacific and today have high rates of obesity and type 2 diabetes (T2DM), possibly due to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Gene Frequency

Share to Genetic Association Studies

Share to Heat-Shock Proteins

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21244673
DOI: 10.1186/1471-2350-12-10
PMCID: PMC3025936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans.PMID 21244673Read ↗

Polygenic and single-locus selection on BMI during Polynesian expansion.Semantic proximity Read ↗

The PPARGC1A Is the Gene Responsible for Thrifty Metabolism Related Metabolic Diseases: A Scoping ReviewSemantic proximity Read ↗

Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A.Semantic proximity Read ↗

A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations.Semantic proximity Read ↗

Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians.Semantic proximity Read ↗

Single nucleotide polymorphisms of thrifty genes for energy metabolism: evolutionary origins and prospects for intervention to prevent obesity-related diseases.Semantic proximity Read ↗

Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in Oceania.Semantic proximity Read ↗

Can evidence from genome-wide association studies and positive natural selection surveys be used to evaluate the thrifty gene hypothesis in East Asians?Semantic proximity Read ↗

The thrifty genotype in type 2 diabetes: an unfinished symphony moving to its finale?Semantic proximity Read ↗

<i>CREBRF</i> missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesians living in Samoa and Aotearoa New ZealandSemantic proximity Read ↗

Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease riskSemantic proximity Read ↗

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.