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Article

Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting

11 Nov 2016

Abstract excerpt

Two zoonotic influenza A viruses (IAV) of global concern, H5N1 and H7N9, exhibit unexplained differences in age distribution of human cases. Using data from all known human cases of these viruses, we show that an individual's first IAV infection confers lifelong protection against severe disease from novel hemagglutinin (HA) subtypes in the same phylogenetic group. Statistical modeling shows that protective HA...

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PMID: 27846599
DOI: 10.1126/science.aag1322

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