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Repeated vaccination with homologous influenza hemagglutinin broadens human antibody responses to unmatched flu viruses

2024-03-29

Abstract excerpt

The on-going diversification of influenza virus necessicates annual vaccine updating. The vaccine antigen, the viral spike protein hemagglutinin (HA), tends to elicit strain-specific neutralizing activity, predicting that sequential immunization with the same HA strain will boost antibodies with narrow coverage. However, repeated vaccination with homologous SARS-CoV-2 vaccine eventually elicits neutralizing activi...

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Identifiers and source

Literature Corpus work
e6575f93-5255-522b-a83c-1f24dd47b47a
DOI
10.1101/2024.03.27.24303943
Open publication

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Repeated vaccination with homologous influenza hemagglutinin broadens human antibody responses to unmatched flu virusesDOI 10.1101/2024.03.27.24303943
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