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Imprinting, immunodominance, and other impediments to generating broad influenza immunity

1 Jul 2020

Abstract excerpt

Natural influenza virus infections and seasonal vaccinations often do not confer broadly neutralizing immunity across diverse influenza strains. In addition, the virus is capable of rapid antigenic drift in order to evade pre-existing immunity. The surface glycoproteins, hemagglutinin, and neuraminidase can easily mutate their immunodominant epitopes without impacting fitness. Skewing human antibody repertoires...

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PMID: 32666572
DOI: 10.1111/imr.12900

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