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Article

Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition.

Oncotarget - 13 Dec 2016

Ekpe-Adewuyi Esther, Lopez-Campistrous Ana, Tang Xiaoyun, Brindley David N, McMullen Todd P W

Abstract excerpt

Recently platelet derived growth factor receptor-alpha (PDGFRα) was recognized as a potential target to treat aggressive papillary thyroid cancer given its strong association with lymph node metastases. However, it is unclear how PDGFRα potentiates metastases and if it works through the canonical MAPK pathway traditionally linked to PTC oncogenesis. We explored the phenotypic changes driven by PDGFRα activation...

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Source

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Identifiers

PMID: 27845909
DOI: 10.18632/oncotarget.13299
PMCID: PMC5347797

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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