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Article

Low-Density Lipoprotein Receptor Is a Key Driver of Aggressiveness in Thyroid Tumor Cells.

International journal of molecular sciences - 6 Jul 2023

Revilla Giovanna, Ruiz-Auladell Lara, Vallverdú Núria Fucui, Santamaría Paula, Moral Antonio, Pérez José Ignacio, Li Changda, Fuste Victoria, Lerma Enrique, Corcoy Rosa, Pitoia Fabián, Escolà-Gil Joan Carles, Mato Eugènia

Abstract excerpt

We previously described the role of low-density lipoprotein (LDL) in aggressiveness in papillary thyroid cancer (PTC). Moreover, the MAPK signaling pathway in the presence of BRAF V600E mutation is associated with more aggressive PTC. Although the link between MAPK cascade and LDL receptor (LDLR) expression has been previously described, it is unknown whether LDL can potentiate the adverse effects of PTC through...

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Share to Cell Line, Tumor
Share to Lipoproteins, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase Kinases

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins B-raf

Share to Receptors, LDL

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 37446330
DOI: 10.3390/ijms241311153
PMCID: PMC10342163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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