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Article

LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.

Oncotarget - 27 Oct 2015

Michelotti Gregory, Jiang Xiaoyin, Sosa Julie Ann, Diehl Anna Mae, Henderson Brittany Bohinc

Abstract excerpt

PURPOSE: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a cancer stem cell marker and a down-stream target in Wnt/β-catenin signaling. In human papillary thyroid cancer (PTC), over activation of Wnt/β-catenin has been associated with tumor aggressiveness. PATIENTS AND METHODS: Using established human cell lines (TPC-1, KTC-1, Nthy-ori-3-1), we report LGR5 and R-spondin (RSPO1-3)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26416247
DOI: 10.18632/oncotarget.5330
PMCID: PMC4741472

Genes

RSPO1
RSPO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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