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Article

PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer.

EBioMedicine - 1 Oct 2016

Lopez-Campistrous Ana, Adewuyi Esther Ekpe, Benesch Matthew G K, Ko Yi Man, Lai Raymond, Thiesen Aducio, Dewald Jay, Wang Peng, Chu Karen, Ghosh Sunita, Williams David C, Vos Larissa J, Brindley David N, McMullen Todd P W

Abstract excerpt

Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptional activity of thyroid transcription factor-1 (TTF1). PDGFRα activation dephosphorylates TTF1 consequently shifting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

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Identifiers

PMID: 27682510
DOI: 10.1016/j.ebiom.2016.09.007
PMCID: PMC5078607

Genes

TTF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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