Article
Identification of R-Spondin Gene Signature Predictive of Metastatic Progression in BRAFV600E-Positive Papillary Thyroid Cancer.
Cells - 29 Dec 2022
da Silva Sabrina Daniela, Morand Grégoire B, Diesel Luciana, de Lima Jefferson Muniz, Bijian Krikor, Kailasam Senthilkumar, Lefebvre Francois, Bourque Guillaume, Hier Michael, Alaoui-Jamali Moulay A
Abstract excerpt
Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland and early stages are curable. However, a subset of PTCs shows an unusually aggressive phenotype with extensive lymph node metastasis and higher incidence of locoregional recurrence. In this study, we investigated a large cohort of PTC cases with an unusual aggressive phenotype using a high-throughput RNA sequencing (RNA-Seq) to...
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