Article
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
The Journal of clinical investigation - 1 Apr 2005
Melillo Rosa Marina, Castellone Maria Domenica, Guarino Valentina, De Falco Valentina, Cirafici Anna Maria, Salvatore Giuliana, Caiazzo Fiorina, Basolo Fulvio, Giannini Riccardo, Kruhoffer Mogens, Orntoft Torben, Fusco Alfredo, Santoro Massimo
Abstract excerpt
In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and activating mutations in the BRAF or RAS oncogenes are mutually exclusive. Here we show that the 3 proteins function along a linear oncogenic signaling cascade in which RET/PTC induces RAS-dependent BRAF activation and RAS- and BRAF-dependent ERK activation. Adoptive activation of the RET/PTC-RAS-BRAF axis induced cell...
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