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Article

Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations.

Laboratory investigation; a journal of technical methods and pathology - 1 Jan 2017

Ng Tsz Kin, Liang Xiao Ying, Lu Fang, Liu David Tl, Yam Gary Hf, Ma Li, Tam Pancy Os, Chen Haoyu, Cen Ling Ping, Chen Li Jia, Yang Zhenglin, Pang Chi Pui

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of visual impairment and irreversible blindness in most developed countries, affecting about 50 million elderly people worldwide. Retinal pigment epithelial (RPE) cell degeneration is the pathophysiological cause of AMD, leading to geographic atrophy and choroidal neovascularization. We and others have previously identified several polymorphisms on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27841854
DOI: 10.1038/labinvest.2016.117

Genes

HTRA1
RPE

Variants

rs11200638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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