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Article

Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients.

Investigative ophthalmology & visual science - 1 May 2008

Kaur Inderjeet, Katta Saritha, Hussain Avid, Hussain Nazimul, Mathai Annie, Narayanan Raja, Hussain Anjli, Reddy Rajeev K, Majji Ajit B, Das Taraprasad, Chakrabarti Subhabrata

Abstract excerpt

PURPOSE: Single nucleotide polymorphisms (SNPs) in the LOC387715 (rs10490924), HTRA1 (rs11200638), and CFH (rs1061170) genes have been implicated in age-related macular degeneration (AMD). The present study was undertaken to determine the involvement of the LOC387715 and HTRA1 in an AMD cohort from India. METHODS: The coding region of LOC387715 (exon 1) and the promoter of HTRA1 were screened by resequencing in...

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Source

Identifiers

PMID: 18436811
DOI: 10.1167/iovs.07-0560

Genes

HTRA1
CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients.PMID 18436811Read ↗

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