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Article

Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity.

Molecular biology of the cell - 1 Feb 2001

Mandic R, Fackler O T, Geyer M, Linnemann T, Zheng Y H, Peterlin B M

Abstract excerpt

The accessory protein negative factor (Nef) from human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) is required for optimal viral infectivity and the progression to acquired immunodeficiency syndrome (AIDS). Nef interacts with the endocytic machinery, resulting in the down-regulation of cluster of differentiation antigen 4 (CD4) and major histocompatibility complex class I (MHCI) molecules...

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Share to Adaptor Proteins, Vesicular Transport
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Antigens

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Share to Proton-Translocating ATPases

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Share to Viral Regulatory and Accessory Proteins

Source

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Identifiers

PMID: 11179428
DOI: 10.1091/mbc.12.2.463
PMCID: PMC30956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity.PMID 11179428Read ↗

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Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and PersistenceSemantic proximity Read ↗

CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.Semantic proximity Read ↗

Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis.Semantic proximity Read ↗

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Mechanisms of CD4 Downregulation by the Nef and Vpu Proteins of Primate Immunodeficiency VirusesSemantic proximity Read ↗

Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.Semantic proximity Read ↗

HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.Semantic proximity Read ↗

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