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Article

Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.

Developmental biology - 1 Jan 2017

Baril Caroline, Gavory Gwenaëlle, Bidla Gawa, Knævelsrud Helene, Sauvageau Guy, Therrien Marc

Abstract excerpt

Acute myeloid leukemia (AML) is a complex malignancy with poor prognosis. Several genetic lesions can lead to the disease. One of these corresponds to the NUP98-HOXA9 (NA9) translocation that fuses sequences encoding the N-terminal part of NUP98 to those encoding the DNA-binding domain of HOXA9. Despite several studies, the mechanism underlying NA9 ability to induce leukemia is still unclear. To bridge this gap,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27838340
DOI: 10.1016/j.ydbio.2016.11.003

Genes

HOXA9
NUP98
PVR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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